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Sholl analysis is a method of quantitative analysis commonly used in neuronal studies to characterize the morphological characteristics of an imaged neuron, first used to describe the differences in the visual and motor cortices of cats.〔Sholl, D.A., 1953. Dendritic organization in the neurons of the visual and motor cortices of the cat. J. Anat. 87, 387–406〕 Initial quantification of a neuron is performed by counting the number of dendrite intersections for concentric circles, usually centered at the centroid of the cell body, of gradually increasing radius. Curves produced by this initial counting are usually of somewhat irregular shape, and much work has been done to determine appropriate means of analyzing the results. Common methods include Linear Analysis, Semi-log Analysis and Log-Log Analysis ==Linear Method== The Linear Method is the analysis of the function N(r), where N is the number of crossings for a circle of radius r.〔 This direct analysis of the neuron count allows the easy computation of the critical value, the dendrite maximum, and the Schoenen Ramification Index.〔Schoenen, J., 1982. The dendritic organization of the human spinal cord: the dorsal horn. Neuroscience 7, 2057–2087〕 Critical Value: The critical value is the radius r at which there is a maximum number of dendritic crossings, this value is closely related to the dendrite maximum. Dendrite Maximum: This value is the maximum of the function N(r), as specified by the Critical Value for a given data set. Schoenen Ramification Index: This index is one measure of the branching of the neuronal cell being studied. It is calculated by dividing the Dendrite Maximum by the number of primary dendrites, that is, the number of dendrites originating at the cell's soma. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sholl analysis」の詳細全文を読む スポンサード リンク
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